Oxycodone reduces pain by acting on the central nervous system . Its effects are: analgesic, anxiolytic, antitussive and sedative . Because oxycodone is exclusively an opioid receptor agonist, its analgesic effect is dose-related with no maximum dose, as long as side effects are controlled.What are the contraindications of oxycodone?
Analgesic: in which cases should this painkiller be used?
Paracetamol, anti-inflammatory, codeine, tramadol… Analgesic drugs are used to reduce or even stop pain. If it is possible to obtain them without a prescription, beware of self-medication, as they can cause undesirable side effects.
What is the mode of action of oxycodone?
Oxycodone is one of the opioid analgesics. It is an agonist of kappa, mu and delta type opioid receptors in the brain, spinal cord and peripheral organs. By binding to these receptors, it activates their therapeutic effects .
Oxycodone may also act on the hypothalamic-pituitary-adrenal (or gonadal) axis causing changes such as increased blood prolactin and decreased cortisol and testosterone . These hormonal changes can manifest themselves in various symptoms.
When to take oxycodone?
Oxycodone is indicated in severe pain that cannot be relieved by lower-level analgesics , such as cancer-related pain, for example.
What is the difference between oxycodone and morphine?
Oxycodone and morphine have a similar mechanism of action . On the other hand, taken orally, the effect of oxycodone on pain is 1.5 to 2 times more powerful than that of morphine (depending on the dose of morphine considered for the comparison). However, this difference is not found for the injectable route, the efficacy on pain of oxycodone being similar to that of morphine. In addition, oxycodone has the advantage of having an effect on neuropathic pain.
Morphine: dosage, effects, drug or not?
Morphine is an opioid, i.e. a derivative of opium. It is classified as a narcotic and its use is highly regulated. However, it remains a prescription drug with a medical indication, most often in the case of chronic pain.
Is it available with or without a prescription?
Oxycodone is a substance on the list of narcotic drugs, which can in no case be delivered without a prescription. In addition, oxycodone must be prescribed by the doctor on a secure prescription , the regulation of narcotics being strictly supervised. Oxycodone prescriptions are only valid for a maximum of 28 days.
What are the side effects and dangers of oxycodone?
Oxycodone has many side effects, some of which can be potentially serious. Among the most common are: digestive disorders ( abdominal pain , constipation, nausea, vomiting), central nervous system disorders (drowsiness, confusion, dizziness, headaches, insomnia, nightmares, hallucinations , anxiety, depression, mood swings), itching or rash, loss of appetite, heavy sweating, dry mouth, urinary retention or trouble urinating, difficulty breathing or bronchial spasms, ‘ hypotension . Alcohol is strongly discouraged during treatment with oxycodone Oxycodone can also causesymptoms of intoxication, such as respiratory depression which can be fatal, dilation of the pupil, slowing of the heart rate , pulmonary edema, circulatory insufficiency, or drowsiness which can progress to a coma. It is therefore essential to avoid any risk of overdose. Similarly, oxycodone can cause abuse, dependence as well as withdrawal symptoms upon discontinuation of treatment. Thus in the event of prolonged intake, a gradual reduction in doses (on medical advice) is necessary.
If you want to read more click here
