Opportunities and Challenges in Short Read Sequencing Market

Introduction

 sequencing technology has advanced significantly. In the beginning, reading DNA letter by letter required painstaking work on the part of scientists. New players have arisen as this sector has developed, providing various tools that can sequence DNA more quickly and effectively.

With these developments, however, there are now more factors to take into account when choosing a sequencing method, such as the amount of coverage required, the number of samples that must be multiplexed, and the ideal read length.

Choosing a platform is an important step in every sequencing project. Short-read and long-read sequencing platforms are the two most popular varieties. Long-read sequencing creates reads that are longer, whereas short-read sequencing generates reads that are shorter, as their names would imply. Depending on the precise objectives of the experiment, each method of sequencing has advantages and disadvantages of its own.

Definition

The term “short read sequencing” refers to a sequencing technique that uses extensive parallelization to sequence many DNA strands. They are renown for benefits including fast processing, great precision, and accurate outcomes. It is use to carry out a variety of tasks, including forensic investigations, biomarker discovery, and customized medicine, among others.

Combining data from short and lengthy reads can be advantageous. Researchers may create high confidence SNP and mutation calls using short read sequencing’s reduced cost per base, high depth, and higher quality data, and then overlay information from long read sequencing on top of that data to resolve complicated SVs and phase haplotypes. Although this necessitates more complex analysis techniques, using both short read and long read sequencing technologies can be very helpful in de novo assembly or rare disease sequencings, allowing for a better understanding of genetic variation.

What is the benefit of short read sequencing?

• A potent tool for producing genomic data is short read sequencing. Short read sequencing allows DNA or RNA to be sequence more quickly and inexpensively than with conventional techniques. This technique has transformed biomedical research and produced significant advancements in the fields of illness, evolution, and genomics. 
• Whole genomes have also been assembled with it, revealing important details about the composition and operation of genes. Short reads are useful for applications that intend to profile the expression of certain transcripts, find variations within otherwise well-conserved sequences, or count the abundance of particular sequences.
• In NGS labs, short-read sequencing has long regard as the workhorse method since it provides the most depth and quality of data at the lowest cost per base. This sector is dominate by the Illumina platform and the Ion Proton technology from Thermo Fisher Scientific.

Opportunities in short read sequencing market

• One of the key factors fueling the expansion of the short read sequencing market is the rise in the incidence of genetic diseases worldwide. The use of sequencing technologies for companion diagnostics and the rise in demand for customized medicine and companion diagnostics as a result of the development of targeted cancer therapies boost market expansion.
• Increased demand for short read sequencing due to its advantages over longer read sequencing, including affordability, simultaneous detection of multiple sequences, high accuracy, and base modifications, among others, as well as increased use of consumables in a variety of procedures, including DNA and RNA sequencing, also have an impact on the market.
• Additionally, the short read sequencing market is favorably impact by population growth, a rise in genetic disease awareness, the expansion of the pharmaceutical and biotechnology industries, and enhanced healthcare infrastructure. Additionally, market participants will have lucrative opportunities thanks to the utilization of improve genetic therapies from 2021 to 2028.
• The ability to quickly sequence the whole human genome thanks to next-gen sequencing has revolutionized the field of genomic research. The genetic material is taken, broken up, and link to various components for amplification during the procedure. Because of its effectiveness and sophistication, this technology is being adopt and growing rapidly. Market expansion is anticipate to be fuel by the increase speed and decrease prices. Applications in forensics, agriculture, and healthcare settings are all expanding quickly.

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Market Insights 

• The rising need for food and the use of next-generation sequencing in healthcare research are two important applications. The diagnosis of more genetic abnormalities has greatly raised the need for next-generation sequencing. In addition, this technology’s usage in drug development is important and is anticipate to spur expansion as the need for efficient medicinal therapy rises.
• The market should have plenty of opportunities for expansion as a result of rising awareness, the use of different growth tactics, and continued technological improvements. The Next Generation Sequencing market, however, has obstacles due to the high initial cost of deploying technologies, the need for storage of massive amounts of data, as well as a dearth of experienced labor to operate the equipment.

Challenges in Short Read Sequencing Market

• This report on the short read sequencing market details recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, the effect of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, and more.
• The short read sequencing market is divide into subgroups base on end-user, product, technology, workflow, and application. The development of these segments will assist you in analyzing the industries’ sparsely growing segments and will give users useful industry overview and market insights to aid in the selection of key market applications.

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